Since C1GALT1 is required for the stabilization of receptor-type phosphoproteins through glycosylation in other carcinomas [24, 28] and to maintain the total PDGFRβ protein expression level in osteosarcoma, we speculate that C1GALT1 may be required for the maintenance of PDGFRβ signaling through glycosylation in osteosarcoma. The gene discussed is C1GALT1; the disease is osteosarcoma.