KNAK4 expression was also upregulated by TGF-β in these fibroblasts; however, the increase in KANK4 expression was markedly more significant in keloid fibroblasts (P = 0.30 and 0.04 in FB2 and FB3, respectively) versus immature scar fibroblasts (Fig. 4b, Supplementary Fig. 4a). This evidence concerns the gene KANK4 and keloid.