Similar to the big data analysis, LCN2 gene expression was significantly increased in patients with NASH; SREBP-1c expression and lipogenic gene expression were strongly correlated with LCN2 gene expression, which was consistent with Lcn2 activation by SREBP-1c and was similar to the findings of our studies in mice (Fig. 8d). Here, LCN2 is linked to metabolic dysfunction-associated steatohepatitis.