Previous research has highlighted the effectiveness of gene signatures in guiding both cancer treatments and prognostic assessments.36,37 Through the utilization of sophisticated LASSO and random forest survival models, we identified four robust genes (JCHAIN, GZMB, IGHA1, and PDRX4) that exhibit significant potential in predicting overall patient survival, exemplified by the AUC values. This evidence concerns the gene GZMB and cancer.