Consistent with the previous findings that inhibition of either CDK4 or PIN1 triggers anti-tumor immunity30,55, we also found that the combination of PIN1 inhibitors and CDK4 inhibitors also create an immune environment with increased infiltration of cytotoxic CD8 + T cells and decreased infiltration of Tregs, raising the possibility that this rewiring of the immune system could further improve the therapeutic effects and increase survival by disrupting the immunosuppressive tumor microenvironment. The gene discussed is PIN1; the disease is neoplasm.