CALR and chronic neutrophilic leukemia: The presence of anti-Ro and/or anti-La antibodies in the maternal circulation are associated with congenital fetal heart block (CHB) and congenital neonatal lupus rash (cNL) [328], with studies suggesting that CHB prevalence is higher in those with high-titre antibodies [329] and those who are positive for both antibodies [330], whilst cNL is higher in female children and those exposed to anti-La antibody [328].