38). Oxidative stress may significantly influence the pathogenesis of psoriasis. Glutathione S-transferase constitutes a group of antioxidant enzymes, and CYP450s can influence oxidative and reductive reactions. In view of this evidence, the potential role of CYP450s in the pathogenesis of psoriasis can be investigated. Clinically, treatments for patients with mild psoriasis include topical corticosteroids, vitamin D analogues, calmodulin neural phosphatase inhibitors, keratolytic medicines and targeted phototherapy (Ref. 39). The gene discussed is HPGDS; the disease is psoriasis.