Consistent with this possibility, we found that the one ΔEBNA2 + Myc tumor-derived cell line (“R3”) that constitutively expresses LMP1 when grown off the CD40L/IL21 expressing feeder cell layer also has a much higher level of total STAT3, phosphorylated STAT3, and Src in comparison to the other cell lines that do not express LMP1 (Fig 9A). The gene discussed is IL21; the disease is neoplasm.