CRISPR/Cas9 screens and other studies have identified cellular genes required for proliferation and survival of human BL cells in vitro, including some like CCND3 (cyclin D3) that are also required for proliferation of normal human GC B cells [48], but are not required for growth and survival of EBV-transformed lymphoblastoid cell lines [49]). This evidence concerns the gene CCND3 and Burkitt lymphoma.