As the transcription factor Myb is expressed at very high levels in the ΔEBNA2 + Myc lymphomas (Fig 5B), and Myb not only serves as a master regulator of GC B cell identity and survival [51,60–62] but is also expressed at very high levels in immature B cells [63–65], we next examined whether Myc activation of Myb is required for regulation of a subset of cellular genes in human BLs. This evidence concerns the gene MYB and lymphoma.