To examine whether Myc repression of LMP1 expression might also be mediated via enhanced DNA methylation of the LMP1 promoters, cell lines derived from the ΔEBNA2 + Myc lymphomas were treated with or without the demethylating agent, 5-azacitadine, and the levels of LMP1 expression were examined by immunoblot analysis (Fig 9E). The gene discussed is MYC; the disease is lymphoma.