Gene sets down-regulated in the Myc-expressing lymphomas include “Hallmark_TNFA_signaling_via_NF-κB” [43] and “Dirmeier_LMP1_Response_Early” [44] (Fig 4C), reflecting Myc’s ability to turn down NF-κB signaling [45] as well as LMP1 expression. This evidence concerns the gene MYC and lymphoma.