Lymphomas infected with ΔEBNA2 EBV alone resemble diffuse large B cell lymphomas with large polymorphous B cells, including some multinucleated cells, while tumors infected with both ΔEBNA2 EBV and Myc are composed of homogenous, medium-sized B cells with distinct cytoplasmic borders and numerous mitotic figures, closely mimicking human BL (Fig 2D). This evidence concerns the gene MYC and lymphoma.