Myc activates expression of the pro-apoptotic BCL2L11 (BIM) gene in B cells [12,13], and Myc over-expression in the transgenic Eμ-Myc mouse model cannot induce B cell lymphomas without additional cellular mutations (in genes such as TP53) that prevent apoptosis and/or senescence in response to Myc [14]. This evidence concerns the gene TP53 and B-cell non-Hodgkin lymphoma.