Consistent with this possibility, we found that the one ΔEBNA2 + Myc tumor-derived cell line (“R3”) that constitutively expresses LMP1 when grown off the CD40L/IL21 expressing feeder cell layer also has a much higher level of total STAT3, phosphorylated STAT3, and Src in comparison to the other cell lines that do not express LMP1 (Fig 9A). This evidence concerns the gene MYC and neoplasm.