MYC and plasma cell myeloma: The “Heller_Silenced_By_Methylation_Up” gene set (which includes cellular genes in multiple myeloma that are silenced by DNA methylation and turned on by demethylating agents) [46] is also down-regulated in Myc-expressing lymphomas (Fig 4C), suggesting that Myc may inhibit expression of some viral and/or cellular genes by inducing DNA methylation.