The finding here that almost all Myc-expressing BL-like tumors in this new model system lose LMP1 expression is reminiscent of previous studies describing the inhibitory effect of NF-κB signaling on Myc-induced BL tumors in mice [28,29], and suggests that EBV-infected Myc-driven BLs cannot occur unless LMP1 expression is turned off. Here, NFKB1 is linked to Burkitt lymphoma.