LMP1 expression was increased by 5-azacitidine treatment, suggesting that enhanced DNA methylation of the proximal (ED-L1) and/or distal (TR) LMP1 promoters in the ΔEBNA2 + Myc lymphoma derived cell lines, as well as in authentic human BLs, helps to repress LMP1 expression. This evidence concerns the gene PDLIM7 and lymphoma.