Interestingly, although high level expression of unphosphorylated STAT3 decreases induction of lytic EBV infection in Burkitt cells in vitro [23,74], we found here that the Myc-expressing tumors have a lower level of EBV lytic gene expression (S2C Fig) despite their decreased STAT3 levels. Here, STAT3 is linked to Epstein-Barr virus infection.