LMP1 expression in the R3 cell line was also associated with a much lower level of Myc expression compared to the other cell lines (including the N3 cell line which was derived from the same tumor) (Fig 9A) as well as a lower level of Myc-induced proteins including Myb, BACH2, TCF3, and CD10 and a much higher level of p100/52 (NF-κB2) (S7 Fig). This evidence concerns the gene BACH2 and neoplasm.