MYC and lymphoma: Immunohistochemical analysis of the (rare) ΔEBNA2 + Myc lymphomas found to express both high level Myc and LMP1 on immunoblot analysis revealed that tumors are composed of geographically distinct foci containing either high level expression of Myc and Myc-induced target genes (including CD10, TDT, TCL1, and CD179B) along with very low level LMP1 expression, or high level LMP1 expression and LMP1-induced Kappa light chain expression, but low-level expression of Myc and Myc-induced target genes (S6 Fig).