MAPT and Alzheimer disease: As gliosis plays a fundamental role in AD pathogenesis,14,15,16,17,18 we evaluated 2 robust glial markers in the human brain across 5 corticolimbic brain regions to compare patterns with tau (phosphorylation-dependent anti-tau antibody 8 [AT8], anti-tau AD antibody [GT-38]) and amyloid-β (6F/3D).