MAPT and Alzheimer disease: Patients with young-onset AD are more commonly observed to have an atypical, nonamnestic clinical syndrome where cortical tau pathology and antemortem tau-PET is observed to be higher.5,29 Taken together, our data extend our previous work that now demonstrates corticolimbic tangle distributions as a flattened score reflecting a constellation of clinically meaningful information that may aid interpretation of medical history.