MAPT and Alzheimer disease: Regional variability in cortical tau and amyloid-β burden,4,7 along with activated microglia/macrophages remains a critical area of study especially in the context of atypical, nonamnestic AD clinical presentations.33,34,35 Our findings suggest that AD brains with lower CLix score may reveal a distinct activated microglia/macrophages signature specific to the hippocampal sparing AD phenotype, which motivates future studies to consider relevance of syndromic presentation.