MSH6 and prostate carcinoma: Currently, there are 14 moderate to high penetrance genes associated with hereditary prostate cancer (ATM, BRCA1, BRCA2, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, RAD51D, and TP53), conferring a 2- to 6- fold increased lifetime risk; however, only 14% of individuals diagnosed with prostate cancer will have a pathogenic variant in one of these genes, suggesting there are additional genetic and environmental factors contributing to development of this disease [2, 3].