KLK3 and Familial prostate cancer: One Finnish-population based retrospective study comparing individuals with and without prostate cancer using a 55 SNV PRS, found a significantly higher percentage of individuals had a PSA level of ≥ 4 ng/mL in the highest PRS quartile compared to the lowest quartile (18.7% vs 8.3%, P-value < 0.00001) suggesting that adding the PRS to PSA testing could contribute additional information in predicting prostate cancer risk [9].