Twenty-one genes including KRAS, TP53, SMAD4, and CDKN2A frequently involved in tumorigenesis and metastasis of pancreatic tumor [1, 29] were compared between organoid groups with metastatic potency (MP, n = 22) and non-metastatic potency (NMP, n = 13) (Fig. 2A). The gene discussed is SMAD4; the disease is pancreatic neoplasm.