B7H3-IL7R-S CAR-T cells significantly promoted tumor eradication and prolonged survival compared to B7H3 CAR-T cells in LN229 tumor-bearing mice (Kaplan − Meier, log-rank tests and Cox regression analyses were used; P < 0.001) (Fig. 6b–c, e). The gene discussed is IL7R; the disease is neoplasm.