Targeting MUC1-C and STAT1 also decreased expression of the SOX2 protein (Fig. 5E and F; Supplementary Fig. S5C and S5D), indicating that MUC1-C/STAT1 signaling integrates regulation of the ∆Np63 and SOX2 genes in HNSCC cells. Here, SOX2 is linked to head and neck squamous cell carcinoma.