Perturbed O-GlcNAcylation has been linked to neurodegenerative diseases and several key etiological factors are known O-GlcNAc substrates, such as tau (Liu et al., 2009; Yuzwa et al., 2012), β-amyloid (Aβ) (Park et al., 2021), neurofilaments (NFs) (Lüdemann et al., 2005), TDP-43 (Zhao et al., 2021), and α-synuclein (Levine et al., 2019; Marotta et al., 2015). This evidence concerns the gene TARDBP and neurodegenerative disease.