Multiple investigations have established RBMS3 as a tumor suppressor gene in cancer,4, 5 and its down‐regulation has been linked to unfavorable prognoses in malignancies such as esophageal squamous cell carcinoma, lung squamous cell carcinoma, nasopharyngeal carcinoma, and gastric cancer.4, 6, 7. Here, RBMS3 is linked to esophageal squamous cell carcinoma.