IFNAR1 and systemic lupus erythematosus: To test whether the IFNAR is required for IgG2c-induced AMIE, as it is for enhancement of alloimmunization during viral infection and systemic lupus erythematosus–like (SLE-like) disease (22, 23, 25), we used IFNAR-KO mice and WT controls in the general experimental design (Figure 1).