In 3 independent studies, ZAP70, FYN, GRAP2, ITK, and CD247 (encoding CD3ζ) were highly upregulated in patients with T-ALL compared with individuals acting as healthy controls or people with other hematopoietic cancers, similar to our murine study (Figure 4A and Supplemental Figure 10A). This evidence concerns the gene FYN and acute lymphoblastic leukemia.