Examining publicly available CRISPR/Cas9 screening data, we found that in T-ALL cell lines the dependency scores of LCK, ZAP70, and CD247 were higher than for other TCR pathway genes, reflecting that the CD3ζ-ZAP70 interaction could be a vulnerable node in T-ALL (Supplemental Figure 10C). Here, ZAP70 is linked to acute lymphoblastic leukemia.