GRAP2 and acute lymphoblastic leukemia: In 3 independent studies, ZAP70, FYN, GRAP2, ITK, and CD247 (encoding CD3ζ) were highly upregulated in patients with T-ALL compared with individuals acting as healthy controls or people with other hematopoietic cancers, similar to our murine study (Figure 4A and Supplemental Figure 10A).