In addition, CD11c expression, an integrin and marker associated with proinflammatory functions when expressed on CD11b+ TAMs (22), was increased in TAMs from Vhl-KO across all clones tested , whereas CD206 expression, a mannose receptor and tumor-promoting TAM marker (23), was decreased (Figure 4, D and E, and Supplemental Figure 3, E and F). Here, VHL is linked to neoplasm.