ITGAM and neoplasm: To determine whether Vhl-KO tumor-infiltrating myeloid cells had a proinflammatory gene signature, we performed bulk RNA-Seq and gene set enrichment analysis (GSEA) on flow-sorted CD11b+ cell populations defined as: M-MDSC (Ly6G–Ly6Chi), TAM1 (F4/80loCD206lo), and TAM2 (F4/80hiCD206hi) (Supplemental Figure 4A).