GNAQ and vascular neoplasm: Although different GNAQ mutations such as p.R183Q and p.Q209L are associated with different classes of vascular anomalies (as CM and vascular tumors, respectively), recent studies highlighted that the transcriptional consequences of these mutations in ECs are similar and include upregulation of pathways such as MAPK, angiogenesis, inflammation, and upregulation of ANGPT2 (28, 60, 65).