In addition, whereas our current study focuses on the characterization of PIK3R3 as an m6A target in a VHL-dependent manner in ccRCC, the functional role of other target genes (such as PCSK9, SMAD6, SCL45A4, and others) in ccRCC remain to be determined and characterized. This evidence concerns the gene PCSK9 and nonpapillary renal cell carcinoma.