The positive role of p85-α on AKT activation in our findings is in contrast with previous reports that p85-α restrains catalytic activity of PI3K and serves as a tumor suppressor in multiple cancer types such as breast cancer, lung cancer, and colorectal cancer (45), suggesting that the effect of the p85 subunit on AKT activation may depend on specific cellular context. Here, PIK3R2 is linked to cancer.