In addition, whereas our current study focuses on the characterization of PIK3R3 as an m6A target in a VHL-dependent manner in ccRCC, the functional role of other target genes (such as PCSK9, SMAD6, SCL45A4, and others) in ccRCC remain to be determined and characterized. Here, PIK3R3 is linked to nonpapillary renal cell carcinoma.