There were 11 atypical variants of the driver genes in PV patients: JAK2 G127D/V392M/S280L/L808W/Y813C/Y1021C, MPL Intron11 c.1653 + 3G > A/P2H/Y591D, CALR R177Q/K391‐E393delKDE; 8 atypical variants of the driver genes were present in ET patients: JAK2 G127D/V392M/K1030R/D1118E, MPL Intron11 c.1653 + 3G > A/R525T/E403D/E416V; 15 atypical variants of the driver genes were present in PMF patients: JAK2 G127D/G281D/D146H/W298R/K304E/L368V/I682delI/Q853E/L925I, MPL C211S/V501A/L629Ifs*51/X636W, CALR A17G/I38M. The gene discussed is MPL; the disease is acquired polycythemia vera.