SARS-CoV-2 infection causes deficient innate immunity by immune dysregulation and a cytokine storm by infecting immune cells (CD3, CD4, and CD8 T cells).26On the other hand, diabetes mellitus affects adaptive immunity by inhibition of neutrophil chemotaxis, phagocytosis, and intracellular killing of pathogens.26Overall, diabetes and corticosteroid usage in COVID-19 patients leads to a high risk of invasive fungal infections. The gene discussed is CD4; the disease is COVID-19.