The present cohort study explored the interaction of DII with FTO gene SNPs in relation to obesity indices.The results indicated that, in individuals with risk allele of FTO SNP rs8050136 (carriers of GA+AA genotypes), greater adherence to DII was associated with increased odds of higher change in WC, but decreased odds of change in WHR. The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.