It is reported that FTO gene affects adiposity by regulating energy intake, energy expenditure and fat distribution.24 Also, FTO expression affects levels of leptin, perilipin and visfatin in adipose tissue, which are involved in various pathways of metabolism.39 The interaction of the DII and FTO SNP on WC has important clinical utility to develop personalised preventive approach for obesity based on genetic context of people that is adapted to meet people’s needs. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.