TCF7L2 and Stroke: TCF7L2: Untreated carriers of the rs7903146 TT genotype have a more than twofold increased risk of stroke due to the more frequent presence of hyperglycaemia and other metabolic risk factors.23 While most people benefit in various ways from a Mediterranean diet (MedDiet) rich in vegetables and virgin olive oil, this 5-year randomised intervention trial suggested a much lower stroke risk compared with the control (4 vs 10.9 incidence rate per 1000 person-years).