APOE and early-onset autosomal dominant Alzheimer disease: Patients with hyperlipidaemia, with the most common combination, APOE E3/3, tend to respond well to standard cholesterol-lowering dietary guidance, including the replacement of saturated fat with monounsaturated fat.18 Carriers of the E2 haplotype, particularly those with two E2 copies and dyslipidaemia, often experience better lipid profiles when they can reduce an excess of body fat.19 Considering the strong, but individually unreliable,20 association of APOE4 with Alzheimer’s disease, the disclosure and discussion of APOE4 carrier status need to be handled very carefully.