AI: artificial intelligence; EEsAI: eosinophilic esophagitis activity index; EGD: esophagogastroduodenoscopy; ECP: eosinophil cationic protein; EndoFLIP®: endoluminal functional lumen imaging probe; EoE: eosinophilic esophagitis; EUS: endoscopic ultrasound; GERD: gastroesophageal reflux disease; HRM: high-resolution manometry; HPF: high-power field; IL: interleukin; IgE: immunoglobulin E; PPI: proton pump inhibitor; PRO: patient-related outcome. The gene discussed is IGHE; the disease is eosinophilic esophagitis.