Among them, ARF1 was significantly overexpressed in 26 cancers (Fig. 1A); ARF3 was significantly overexpressed in 26 cancers and only low in glioblastoma multiforme (Fig. 1B); ARF4 was significantly overexpressed in 26 cancers (Fig. 1C); ARF5 was significantly overexpressed in 28 cancers and only low expressed in esophageal carcinoma (Fig. 1D); ARF6 was significantly overexpressed in 23 cancers, while it was low expressed in esophageal carcinoma and skin cutaneous melanoma (Fig. 1E). The gene discussed is ARF5; the disease is cutaneous melanoma.