In this study, the favorable prognosis of patients with a high density of TOB1+CD66b+ neutrophils might be due to alterations in TOB1 expression levels upon neutrophil infiltration into the tissue, leading to changes in neutrophils apoptosis and subsequently influencing tumor progression, even by modulating immunotherapy to enhance the prognosis of gastric cancer patients. The gene discussed is CEACAM8; the disease is neoplasm.