The densities of nTOB1+CD4+ T cells, cTOB1+CD4+ T cells, nTOB1+CD20+ B cells, and cTOB1+CD20+ B cells were significantly lower in cancer tissues than in paracancerous tissues (P < 0.001, P < 0.001, P < 0.001, and P < 0.001, respectively). Here, CD4 is linked to cancer.