In contrast, the densities of nTOB1+FOXP3+ Tregs, cTOB1+FOXP3+ Tregs, nTOB1+CD68+ macrophages, and cTOB1+CD68+ macrophages were higher in cancer tissues than in paracancerous tissues (P = 0.003, P < 0.001, P < 0.001, and P < 0.001, respectively). This evidence concerns the gene FOXP3 and cancer.