This interaction may result in direct tumor cell killing through antibody-dependent cellular cytotoxicity (37).TOB1 may regulate the TGF-β pathway in activated T cells by inhibiting twisted gastrulation (38), and there was substantial evidence to confirm that TGF-β induction led neutrophils towards a pro-tumor phenotype within the tumor microenvironment (39, 40). This evidence concerns the gene TGFB1 and neoplasm.