CXCL1 and neoplasm: Han et al. observed that TNBC-derived C-X-C motif chemokines 1/2/8 (CXCL1/2/8) stimulate CAFs and other lung-resident fibroblasts to secrete C-C motif chemokines 2/7 (CCL2/7), thereby activating cholesterol synthesis in TNBC cells to support metastatic tumor growth 30.