TP53 and hepatocellular carcinoma: In addition, squalene epoxidase (SQLE), the rate-limiting enzyme of cholesterol biosynthesis, has also been shown to promote the progression of p53-deficient castration-resistant prostate cancer (CRPC) 61, proliferation of p53 wild-type HCC cells, liver tumorigenesis in p53 knockout mice 62, and colorectal carcinogenesis by promoting gut dysbiosis 63.