Like in the CaPO4-injuried mice (Fig. 1), AAA lesions from colchicine-treated Apoe-/- mice also showed much less media elastica fragmentation, SMC loss and apoptosis, lesion macrophages accumulation, microvessel counts, and endothelial VCAM-1 expression, than those of saline-treated mice, but there were no differences in SMC proliferation between the groups (Fig. S1 and Fig. S2C). This evidence concerns the gene VCAM1 and triple-A syndrome.