CNN1 and triple-A syndrome: We detected similar phenotypic changes of vascular SMCs in Ang-II-induced AAA lesions from colchicine-treated Apoe-/- mice compared with saline-treated control Apoe-/- mice, including increase of lesion TAGLN+α-SMA+ SMCs and KLF4 expression in ECs, decrease of lesion KLF4+α-SMA+ and CD68+α-SMA+ SMCs, reduction of plasma inflammatory cytokines (TNF-α, IL-1β, IL-6), increases of lesion expression of ACTA2, TAGLN, MYH11, and CNN1, and inhibition of lesion expression of KLF4, MMP2, MMP9, IL-6, TNF-α, and IL-1β (Fig. S2D and Fig. S7).