A study by Nishio et al. demonstrated that CAR-T cells armed with adenovirus expressing chemokine (C-C motif) ligand 5 (CCL5, better known as RANTES) and cytokine interleukin (IL)-15, specifically augmented CAR-T cell migration and proliferation in a xenotransplant human neuroblastoma murine model, ultimately leading to enhanced tumor-bearing mice survival 32. This evidence concerns the gene IL15 and neuroblastoma.