CD274 and neoplasm: The TIME has also been classified based on the presence or absence of tumor infiltrating lymphocytes (TILs) and PD-L1 expression: type I (PD-L1 positive with the presence of TILs, driving adaptive immune resistance), type II (PD-L1 negative with absence of TILs, indicating immune ignorance), type III (PD-L1 positive with absence of TILs, indicating intrinsic induction), and type IV (PD-L1 negative with the presence of TILs, indicating the role of other suppressors in promoting immune tolerance) 28.