In addition, we collected 6 cases of CRC tissues, and found that 3 cases of CRC patients with PTPLAD1-low displayed high level of EMT (evidenced by the increase of vimentin and decrease of E-cadherin), mitofission (evidenced by the increase of Fis1 and decrease of MFN1/2) and ERK signaling activity (evidenced by the upregulation of p-ERK) (Supplementary Fig. 5E). This evidence concerns the gene HACD3 and colorectal carcinoma.