NFKB1 and familial dilated cardiomyopathy: In DCM, activating PI3K/AKT signal pathway or inhibiting NF‐κB signal pathway could reduce the occurrence of IR,119, 120 and AKT2 deficiency resulted in severe glucose intolerance, myocardial contractile dysfunction, cardiomyocyte apoptosis, and impaired cardiac function.121, 122