Furthermore, the positive correlations we found for Ruminococcaceae_UCG-014 with IL-6 and ADR suggest that CRS exposure may have resulted in persistent intestinal inflammation and the hypothalamus-pituitary-adrenal (HPA) axis activation via increasing the abundance of this particular bacterial genus, along with a general disruption of the gut microbiome as described earlier. The gene discussed is IL6; the disease is congenital rubella syndrome.