The positive rate of 5-HT has been shown to be increased sequentially in patients with non-atrophic gastritis, intestinal metaplasia and gastric cancer 27, 5-HT can enhance the cell viability of gastric adenocarcinoma, reduced cellular and lipid reactive oxygen species, and suppressed ferroptosis via triggering HTR2B-mediated PI3K/Akt/mTOR signaling pathway 28. Here, AKT1 is linked to gastric adenocarcinoma.