By evaluating the influence of stress and the involvement of CRH on experimental colitis in rats, it is observed that centrally injected CRH antagonist, alpha-helical CRH-(9-41) has no effect on trinitrobenzenesulfonic acid-induced colitis but enhances the effects of stress on colitis, suggesting that central CRH may only participate in controlling the process of colitis in case of stress (66). This evidence concerns the gene CRH and colitis.