Consistent with previous results in mouse fibroblasts that demonstrated the resistance of ROCK1 NC to caspase-mediated proteolysis (Julian et al., 2021), treatment of lymphoma cells with a combination of the BCL-2-selective inhibitor ABT199 (Souers et al., 2013) and cycloheximide (Chx) to induce apoptosis resulted in protein cleavage of ROCK1 WT but not ROCK1 NC (Fig. 1A). Here, BCL2 is linked to lymphoma.