There was a significant change in the observed disease spectrum, with an over 4-fold increased proportion of mice with thymic B cell lymphomas, and concomitant ∼40% decreases in the proportions of B cell lymphomas located in spleen and lymph nodes as well as of multicentric B cell lymphomas in which thymus, spleen and lymph nodes were grossly affected tumour sites (Fig. 1D) in Eμ-Myc; Rock1 NC mice relative to those in Eμ-Myc; Rock1 WT mice. Here, ROCK1 is linked to B-cell non-Hodgkin lymphoma.