Moreover, Drp1‐dependent mitochondrial fission and enhanced glycolysis are associated with alterations in antioxidant enzyme activity and dysfunction of the mitochondrial electron transport chain (ETC), resulting in massive mitochondrial ROS (mtROS) production, and this increase in mtROS activates the NLRP3 inflammasome to stimulate a large release of inflammatory mediators to form an anoxic and inflammatory microenvironment, which ultimately promotes the development of PHG and GC. The gene discussed is NLRP3; the disease is gastric cancer.