In response to HIF‐1α‐mediated ROS release from dysfunctional mitochondria under hypoxia, the NLRP3 inflammasome is swiftly activated, and IL‐18 and IL‐1β are secreted with the assistance of cleaved caspase‐1 and GSDMD‐N, which boosts extracellular inflammation and eventually aggravates gastric mucosal inflammatory lesions in PHT and promotes the proliferation of gastric carcinoma cells. The gene discussed is IL1B; the disease is gastric carcinoma.