Moreover, the activation of the inflammasome NLRP3, which was associated with the secretion of the inflammatory mediators IL‐18 and IL‐1β, was significantly enhanced in PHT‐mediated gastric mucosal injury in both humans and mice, and PX‐478 repressed this process (Figure 9A,B). This evidence concerns the gene IL18 and pulmonary hypertension, primary, 1.