PX‐478‐mediated HIF‐1α inhibition and Mdivi‐1‐mediated Drp1 inhibition both restored mitochondrial function to a certain extent, which alleviated PHT‐induced gastric mucosal injury and blocked GC cell proliferation, suggesting that HIF‐1α mediated mitochondrial dysfunction via Drp1‐dependent mitochondrial fission. This evidence concerns the gene HIF1A and pulmonary hypertension, primary, 1.