In our study, we further analysed the cell death outcomes of mitochondrial dysfunction‐mediated ROS production by HIF‐1α under hypoxia by evaluating the possibility of apoptosis, necrotic apoptosis, ferroptosis and pyroptosis in gastric mucosal lesions in PHT and GC, and we revealed that the protein levels of NLRP3 and cleaved caspase‐1, rather than those of MLKL, FTH and FTL, were increased in both HIF‐1α‐transfected GES‐1 cells and cells isolated from SGC7901 xenograft mouse models but could be decreased by PX‐478 treatment in cells from SGC7901 xenograft mice. The gene discussed is NLRP3; the disease is gastric cancer.