U2AF1 and myeloid neoplasm: Furthermore, mutation driver genes SRSF2, U2 small nuclear RNA auxiliary factor 1 (U2AF1), and the epigenetic regulator isocitrate dehydrogenase 1 and 2 (IDH1/IDH2) are recurrently mutated in numerous myeloid neoplasms and are associated with unfavorable clinical prognosis [154–159].