Although impaired lung function was substantially associated with all selected biomarkers except monocyte percentage, hematocrit percentage, urea, and ALT, only some of them were significant predictors of depression risk, such as leukocyte count, neutrophil count and percentage, lymphocyte count and percentage, CRP, platelet count, erythrocyte count, RBC distribution width, hemoglobin concentration, cystatin C, urate, ALP, AST, GGT, TBIL, TP, and ALB (FDR < 0.05) (Additional file 1: Table S9). Here, CRP is linked to major depressive disorder.