MFF and Dravet syndrome: In addition, we confirmed the presence of mitochondrial abnormalities in the brain of Ts2 mice, similar to the molecular changes found in the brain of individuals with DS, including a sex-independent elevation in DS of the phosphorylation of DRP1 at position 616 (p-DRP1) as compared to the respective diploid controls, and higher expression of the mitochondrial fission factor MFF, both markers of mitochondrial fragmentation [9, 35] (Fig. 2).