Moreover, NaB impedes high glucose-induced NLRP3 overexpression in human monocyte macrophage THP-1 cells, negatively regulates NLRP3-mediated inflammatory signaling pathways, suppresses macrophage activation and secretion of pro-inflammatory mediators (such as IL-18 and IL-1β), reduces intestinal inflammation level, and limits colitis-associated cancer development [22, 23]. Here, NLRP3 is linked to colitis.