PIK3CA and squamous cell lung carcinoma: For example, Okudela K et al. [74], by using immortalized airway epithelium 16HBE14o- cells, showed that the effects of the PIK3CA mutation at K545E and H1047R were more remarkable than those of wild-type PIK3CA in the promotion of proliferation and invasion of lung squamous cell carcinoma (LUSC) cells.