However, the notion that PIK3CA mutations are susceptible to PI3K inhibitors seems to have been challenged by a recent study conducted in cervical carcinoma [90] in which no striking association was observed between PIK3CA mutation and sensitivity to PI3K/AKT/mTOR inhibitors in cervical squamous cell carcinoma cell lines. The gene discussed is PIK3CA; the disease is cervical squamous cell carcinoma.