This category is a newly introduced as “AML with NUP98 rearrangement” in WHO2022 and as “AML with t(5;11)(q35.2;p15.4)/NUP98::NSD1 and with t(11;12)(p15.4;p13.3)/NUP98:KMD5A and NUP98 and other partners” in ICC. The gene discussed is NSD1; the disease is acute myeloid leukemia.