VEGFC and neoplasm: Reports have indicated that the VEGF-C-induced peritumor lymphatics exhibited abnormal function.28 One possible reason for the decrease of IFP following SAR131675 treatment is that the anti-lymphangiogenesis activity of SAR131675 normalizes the function of the existing peritumoral LVs which might enhance the drainage of fluid in tumor tissue, leading to a further decrease in intratumoral IFP.