A 63-year-old man (Case 3, III-4) (Fig. 5) with sebaceous cancer (MSH2/MSH6) was found to carry a BRCA1(NM_007294.4:c.2800C>T) pathogenic nonsense variant (supplementary Fig. 1), and a 57-year-old man (Case 14, III-6) (Fig. 6) with small-bowel cancer (MSH2/MSH6 loss) was found to carry a POLQ variant (NM_199420: c.245_250delinsTGTA) which probably affects function (supplementary Fig. 2). Here, MSH6 is linked to sebaceous adenocarcinoma.