Using MMR-IHC, we previously performed universal tumor screening for identification of LS, and reported the proportion of at least three categorized dMMR tumors in nine different tumors, including CRC, gastric cancer (GC), small-bowel cancer (SBC), EC, ovarian cancer (OC), upper urinary tract cancer (UUTC), urinary bladder cancer (UBC), prostate cancer (PC), and sebaceous tumor (ST) [12, 16–23]. Here, MRC1 is linked to colorectal carcinoma.