Other significant studies from Latin American countries have assessed the frequency of BRAF V600E mutation in ameloblastomas by immunohistochemical analysis: Fregnani et al. (20) reported a frequency of 46.6% from 73 cases; Canto et al. (9) reported a frequency of 78.6% from 84 cases; Santana et al. (21) reported a frequency of 66.7% from 30 cases; and Marcelino et al. (8) reported a frequency of 81.2% from 128 cases. The gene discussed is BRAF; the disease is ameloblastoma.