Alongside a common mutation background, clone-specific BCR::ABL1 compound mutations and mutations in other leukemia-related genes were identified, including Clone 1P2 (BCR::ABL1-T315I + H396R + I418T), Clone 1P3 (BCR::ABL1-T315I + E255V; IKZF1-E383G), Clone 1P4 (BCR::ABL1-T315I + H396R), Clone 1P5 (BCR::ABL1-T315I + E250G; SETD1B-G1963fs), and Clone 1P6 (BCR::ABL1-T315I + Y253H; ZRSR2-R451H). Here, BCR is linked to leukemia.