However, no effective early warning and diagnostic blood biomarkers have been established, although biomarkers such as Aβ42/Aβ40 [5], phosphorylated tau (p-tau) [6, 7], neurofilament light (NfL) [8], and glial fibrillary acidic protein (GFAP) [9, 10] have demonstrated some efficacy in the early diagnosis of AD. The gene discussed is NEFL; the disease is Alzheimer disease.