Firstly, we must emphasize the excellent performance of SV2A in the diagnosis of AD, of which the AUCs of the CSF and serum SV2A were 91.37% and 86.6%, respectively, and the decrease of CSF and serum SV2A levels in patients with AD was consistent with the trend in SV2A PET [17]. Here, SV2A is linked to Alzheimer disease.