In this study, the mouse strains used were normal C57BL/6 and B6/JGpt-Tg(hSNCA-A53T)62/Gpt transgenic mice, whereas in the AD study, B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax transgenic mice were used. This evidence concerns the gene PSEN1 and Alzheimer disease.