α-Synuclein (αSyn), well-known for its involvement in Parkinson’s disease (PD) [1–3], is implicated in other synucleinopathies, namely Lewy Body dementias (LBD), which include Dementia with Lewy Bodies (DLB) and PD with dementia (PDD). The gene discussed is SNCA; the disease is Lewy body dementia.